Nicotine Absorption Profile Among Regular Users of a Pod-Based Electronic Nicotine Delivery System
A za one sto ih mrzi da citaju sve
"Among experienced users who took 30 puffs in 10 minutes, the pod-based ENDS delivered a mean nicotine boost of 28.6 ng/mL in a mean of 8.7 minutes. This is higher and faster than the mean nicotine boost obtained from “cigalike” ENDS devices (puff activated and similar size and shape as a traditional tobacco cigarette; 1.8 ng/mL, 10 minutes) and advanced ENDS devices (button-activated with larger battery; 10.8 ng/mL, 12.1 minutes) using the same puffing schedule.4 These users also self-reported higher nicotine dependence on the PSECDI, compared with 3609 experienced long-term users of other ENDS devices (mean PSECDI score, 8.1).
This study is the first, to our knowledge, to show that JUUL delivers a higher and faster boost in blood nicotine than has been reported for most other ENDS devices.4-6 Limitations are the small sample size and that ENDS users may not typically take 30 puffs in 10 minutes. However, its use produced a mean (SD) nicotine boost of 12.9 (9.
ng/mL after only 12 puffs in 4 minutes, a rate suggestive of pulmonary absorption. Compared with studies reporting the nicotine boost obtained after smoking 1 cigarette, this product’s nicotine delivery was similar.4,6 The nicotine delivery capabilities of this ENDS device may contribute to its addictiveness as well as its ability to compete with cigarettes for market share."